Study Description. The objective of this study is to investigate the interaction between marijuana and quetiapine, with the goal of using this information to improve marijuana treatment outcome.
Detailed Description:. The purpose of this study is to determine if quetiapine decreases marijuana relapse in a controlled lab setting. For the purposes of this model, relapse is defined as a return to marijuana use after a period of abstinence. Participants will begin taking capsules as outpatients so that the dose can be incremented prior to the inpatient phase. While inpatient, participants will have the opportunity to self-administer placebo 0.
Our laboratory model, which has distinguished the effects of a range of medications on marijuana withdrawal and relapse, will provide important information on the effect of quetiapine as a potential short-term pharmacotherapy to facilitate abstinence in the initial stages of marijuana treatment. Drug Information available for: Quetiapine. FDA Resources.
Arms and Interventions. Outcome Measures. Eligibility Criteria. Inclusion Criteria: Current marijuana use:average of 2 marijuana cigarettes per day at least 4 times per week for the past 4 weeks Able to perform study procedures years of age Women practicing an effective form of birth control condoms, diaphragm, birth control, pill, IUD Normal body weight Exclusion Criteria: Current, repeated illicit drug use other than marijuana Presence of significant medical illness e.
Avoid drinking alcohol or using illegal drugs while you are taking quetiapine. They may decrease the benefits e. If an overdose occurs call your doctor or You may need urgent medical care.
You may also contact the poison control center at Increased blood pressure, increased heart rate, drowsiness, headache, agitation, dizziness, fatigue, extrapyramidal symptoms, weight gain, cholesterol abnormalities, increased glucose, dry mouth, increased appetite, constipation.
Quetiapine may increase the blood levels of a hormone called prolactin. Side effects of increased prolactin levels include females losing their period, production of breast milk and males losing their sex drive or possibly experiencing erectile problems. Long term months or years of elevated prolactin can lead to osteoporosis, or increased risk of bone fractures.
Some people may develop muscle related side effects while taking quetiapine. Symptoms of EPS include restlessness, tremor, and stiffness.
TD symptoms include slow or jerky movements that one cannot control, often starting in the mouth with tongue rolling or chewing movements.
Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, and dehydration. Second generation antipsychotics SGAs increase the risk of weight gain, high blood sugar, and high cholesterol.
This is also known as metabolic syndrome. Your healthcare provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c a measure of blood sugar over time while you take this medication. Information on healthy eating and adding exercise to decrease your chances of developing metabolic syndrome may be found at the following sites:. SGAs have been linked with higher risk of death, strokes, and transient ischemic attacks TIAs in elderly people with behavior problems due to dementia.
All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia irregular heartbeat. To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks.
Your doctor may order an EKG to monitor for irregular heartbeat. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your healthcare provider immediately. All antipsychotics can cause sedation, dizziness, or orthostatic hypotension a drop in blood pressure when standing up from sitting or lying down.
These side effects may lead to falls which could cause bone fractures or other injuries. This risk is higher for people with conditions or other medications that could worsen these effects. If falls or any of these symptoms occur, contact your healthcare provider. Tardive dyskinesia TD is a side effect that develops with prolonged use of antipsychotics. If you develop symptoms of TD, such as grimacing, sucking, and smacking of lips, or other movements that you cannot control, contact your healthcare provider immediately.
Table 6 Therapies provided to patients who intentionally abused second-generation antipsychotics SGA. CPR, cardiopulmonary resuscitation.
Extended-release quetiapine fumarate quetiapine XR : a once-daily monotherapy effective in generalized anxiety disorder. Data from a randomized, double-blind, placebo- and active-controlled study. Int J Neuropsychopharmacol. Intranasal quetiapine abuse.
Am J Psychiatry. Intravenous quetiapine abuse. Morin AK. Possible intranasal quetiapine misuse. Am J Health Syst Pharm. Quetiapine addiction? Additional evidence of the abuse potential of quetiapine. South Med J. Addictive potential of quetiapine. Quetiapine: another drug with potential for misuse?
A case report. J Clin Psychiatry. The role of antihistaminic effects in the misuse of quetiapine: a case report and review of the literature. Neurosci Biobehav Rev. Acute dyskinesia, myoclonus, and akathisa in an adolescent male abusing quetiapine via nasal insufflation: a case study. BMC Pediatr. Evaluation of quetiapine abuse and misuse reported to poison centers.
J Addict Med. Misuse of atypical antipsychotics in conjunction with alcohol and other drugs of abuse. J Subst Abuse Treat. Tcheremissine OV. Is quetiapine a drug of abuse? Reexamining the issue of addiction. Expert Opin Drug Saf. Acute quetiapine overdose in adults: a 5-year retrospective case series.
Ann Emerg Med. A systematic review of cardiovascular effects after atypical antipsychotic medication overdose. Am J Emerg Med.
Clinical and analytical features of severe suicidal quetiapine overdoses-a retrospective cohort study. Clin Toxicol. Quetiapine poisoning: a case series. Fatal overdoses associated with quetiapine. J Anal Toxicol. Bartos M, Knudsen K. Use of intravenous lipid emulsion in the resuscitation of a patient with cardiovascular collapse after a severe overdose of quetiapine.
Lannemyr L, Knudsen K. Severe overdose of quetiapine treated successfully with extracorporeal life support. Approved May 7, Clin Toxicol Phila ; 52 10 — If you experience any of the issues above while using Seroquel, talk to your doctor as soon as possible to discuss the best next steps. Seroquel can interact with certain other medications. It should not be combined with antiarrhythmic drugs, certain antibiotics, antipsychotic drugs, alcohol, or methadone.
These drugs include benzodiazepines, muscle relaxants, certain pain medications, antihistamines, and sedatives. You should always use Seroquel according to dosage. Your individual dosage will expend on your age, what condition you have, and other factors. If addiction occurs, inpatient treatment is likely the best solution. An inpatient program will begin with detoxing, which allows patients to experience the effects in withdrawal in a comfortable and healthy environment.
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